If you are considering the means to normalize the work of the digestive tract, often choose one of the most common drugs: Motilium or Motilak. They are used to eliminate the symptoms of overeating: nausea, vomiting. In addition, the active component in the composition helps to restore the functions of the gastrointestinal system. When choosing a drug, they are compared by their basic properties.
Both drugs contain the same active substance - domperidone. Its main function is to provide an anti-emetic effect. Thanks to domperidone passes nausea. The desired effect is achieved by increasing the pressure of the lower esophageal sphincter. Slow heartburn. By increasing the pressure of the sphincter, food penetration into the esophagus is eliminated. This avoids belching.
The drug contributes to the normalization of gastrointestinal motility. This restores the function of the digestive tract. At the same time decreases the intensity of gas. Food digests faster, gastric emptying accelerates.
Features of drugs
Motilium can be purchased in the form of tablets (film coated, lingual), suspensions. Domperidone concentration is different in each case. 1 tablet contains 10 mg of the substance, 1 ml of the suspension contains 1 mg of domperidone. For comparison, Motilak can be purchased only in the form of tablets (coated, lingual). The concentration of the active substance in the composition of the drug tablet form is the same.
Characteristics of the active substance
Domperidone provides the desired effect due to the ability to show antagonistic properties against dopamine. Moreover, the active component does not penetrate the blood-brain barrier. As a result, domperidone helps to reduce the intensity of vomiting due to the combined action: gastrokinetic and antagonistic properties, but already in relation to dopamine receptors located in the chemoreceptor trigger zone, which is located outside of the hematoencephalic barrier.
What is better Motilak or Motilium
Both drugs act on the same principle. This is due to the fact that it contains the same active ingredient. Its concentration in 1 tablet does not change. This means that these funds are considered direct substitutes for each other. Motilium has an advantage - it can be purchased in different forms: tablets, suspension. Motilak in liquid form is not made.
Compatibility of Motilium and Motilaka
Given that these funds contain the same active ingredient and do not differ in dosage, it is impractical to use them simultaneously. Both products have the same effect. If you want to enhance the effect of the drug, changing the dosage of the suspension or tablets in a big way. Apply in this case, 2 different drugs should not be, although the same result will be provided. When Motilium and Motilak are combined, the intensity of domperidone action on the body increases.
Indications for use
Preparations based on Domperidone are recommended for use in some cases:
- diseases of the digestive tract: gastro-esophageal reflux, pancreatitis, esophagitis, as well as pathological conditions, accompanied by a feeling of fullness in the stomach;
- fast saturability when eating food;
- vomiting with nausea;
- pain in upper abdomen.
Indications for use are nausea and vomiting not only against the background of overeating, gastrointestinal diseases, but also due to the development of infectious diseases, radiotherapy, drug therapy.
Dosing and Administration
The treatment regimen differs depending on the type of pathological condition. Before using the drug in the form of lozenges, study the instructions for use:
- digestive disorders in adults and children from 5 years: 10 mg three times a day;
- vomiting, nausea in patients 12 years and older: 20 mg 3-4 times a day.
Schemes for the use of coated tablets do not differ. The drug in such forms is recommended to be used 15-30 minutes before meals. If necessary, take 1 dose of medication at bedtime.
Suspension is prescribed in the same dosage: 10-20 ml at a time. The specified amount contains 10-20 mg of active substance. The frequency of admission - up to 4 times a day. Children up to 12 years old are prescribed a drug based on weight: 0.25-0.5 ml / kg.
When it is planned to take drugs based on domperidone and antacids, it is necessary to take breaks between doses. To this end, the last of the drugs taken after meals.
The composition includes a substance sorbitol. If intolerance to this component develops, the drug should be replaced with a direct analogue in the form of tablets.
The active ingredient is excreted by the kidneys. If severe pathologies of this organ develop, the dose of the drug may be reduced. In addition, reduce the frequency of application of the drug to 1-2 times a day.
Pregnancy and lactation
The effects of domperidone on the woman's body when carrying a child, as well as on the fetus, are not fully understood. Hence, it is not known whether the active substance has an effect on the body in this case. For this reason, Motilium and Motilak are prescribed on condition that the probable benefit exceeds the potential harm.
It is proved that domperidone has the ability to penetrate into breast milk. Its concentration varies in the range of 10-50% of the dosage of the drug in the plasma of a woman. Hence, part of the active ingredient enters the body of the child. There is no information about how domperidone affects infants. For this reason, it is better to complete or interrupt lactation for the duration of drug treatment.
Means based on domperidone can be prescribed to infants, patients of preschool age. Moreover, it is important to correctly calculate the dosage. This is due to the fact that with the treatment of Motilium or Motilak, the risk of neurological side effects increases.
The drug should be used with caution in patients older than 60 years. This is due to the increased risk of ventricular arrhythmia, the onset of coronary death. Such effects are observed if the drug is taken in an amount of 30 mg or more per day.
Side effects Motiliuma and Motilaka
In most cases, treatment with drugs of these types is well tolerated, without consequences. Rarely side effects occur:
- allergies: rash, urticaria, anaphylactoid reactions;
- convulsive tissue contractions;
- extrapyramidal disorders;
- ventricular arrhythmia;
- sudden coronary death;
- violation of the process of urine;
- changes in liver function and prolactin;
- bowel cramps.
Domperidone-based preparations are prohibited for use in some cases:
- individual intolerance to the active or auxiliary components in the composition;
- pituitary tumor prolactin secreted nature;
- bleeding in the digestive tract;
- perforation of the digestive tract;
- intestinal obstruction;
- diseases of the liver moderate and severe.
- kidney disease;
- pathological conditions accompanied by an increase in the QT interval, congestive heart failure.
Impact on driving
Drugs containing domperidone do not affect concentration. It is permissible to drive a vehicle while receiving funds Motilium and Motilak.
Interaction with other drugs
Preparations containing domperidone are forbidden to combine with the group of inhibitors of the CYP3A4 enzyme, which prolong the QT interval.
Neutralization of the effects provided by Motilium and Motilak occurs when these drugs are combined with anticholinergic drugs.
It is permissible to use considered drugs containing domperidone with neuroleptics and dopaminergic receptor agonist agents.
Compatibility with alcohol
It is recommended to take a long break between drinking alcoholic beverages and taking such medications as Motilium and Motilak. The simultaneous entry of domperidone and ethanol into the blood will lead to a decrease in the effectiveness of the drug.
Uncontrolled medication contributes to the development of extrapyramidal reactions, disorientation in space, drowsiness. Effective therapeutic measures: prescribe activated angle or another sorbent, washed the stomach.
Pharmacy sales terms
Tablets in a film cover and lingual can be got over the recipe. Suspension refers to prescription drugs.
Recommended storage temperature: + 15... + 30 ° С.
The drug in different forms is permissible to be stored for a period of different duration:
- 2 years for lingual tablets;
- 3 years for suspension;
- 5 years for coated tablets.
Instead of Motilium and Motilaka, other medicines may be prescribed:
- Motilium Express;
Motilium can be purchased for 450-700 rubles. Price depends on the form of release. Suspension is the most expensive variety of Motilium. Resorption tablets are cheaper - 450 rubles. The average price category includes coated tablets. Their cost is 670 rubles. (pack of 30 pieces). For comparison, Motilak tablets can be purchased for 350 rubles, which is much less than the cost of Motilium.
Anna, 34 years old, Permian
In comparison with solutions for intravenous administration, Motilium tablets for sucking is much more convenient to use. Simple tablets with nausea often provoke vomiting, and the medicine for sucking quickly solves the problem, and there is no urge to vomit.
Veronica, 29 years old, Sevastopol
Motilak costs much less than Motilium, and by the mechanism of action the means are identical. I buy it from nausea, it helps quickly. But Motilak is sold only in tablets, which is not suitable for everyone. For example, in case of severe vomiting, the medicine in this form is not recommended.