Antioxidant drugs such as mexiprim or mexidol are not only able to bind excess free radicals in the body, but also have a beneficial effect on brain activity and peripheral blood flow. Therefore, they are often prescribed for the correction of abnormalities arising as a result of impaired cerebral circulation, intake of antipsychotics or alcohol abuse. The choice between them depends on the features of the pathology and individual reactions.
Indications for use
Medicines can be used for therapeutic and prophylactic purposes. Indications:
- a mild form of cognitive impairment of atherosclerotic genesis, loss of memory and intellectual productivity, the beginning of the development of senile dementia, infantilism;
- impaired blood supply to the brain, including with vertebral lesions;
- angiodystonia, VSD;
- encephalopathy, lacunar status, hemorrhag
- anxiety and neurotic disorders, panic attacks;
- stressful conditions, work in extreme conditions, school neurosis, emotional shock, chronic fatigue;
- intracranial trauma, concussion;
- withdrawal syndrome, poisoning by psychotropic substances.
As part of the drug complex, they are prescribed for acute forms of myocardial infarction, angle-closure glaucoma, necrotic pancreatitis, peritonitis, CNS infections (encephalitis, myelitis, encephalomyelitis).
What is the difference between these drugs?
The main difference between the two is the additional composition. Means are produced in the form of tablets and injections for intravenous or intramuscular administration. The injection form of meciprim, in addition to the active substance, contains only bidistilled water, the oral option, in addition to general additives, includes kaolin and sodium starch glycolate.
Mexidol injections additionally contain sodium metabisulfite, which sometimes causes severe allergic reactions in asthmatics, and in tablets - lactose monohydrate, which limits their intake in case of galactose intolerance, lactase deficiency and glucose-galactose syndrome malabsorption.
Characteristics of active substances
Mexidol and Meciprim are drugs that improve blood circulation and nutrition of the brain. Their active composition is represented by ethylmethylhydroxypyridine succinate, which is a derivative of vitamin B6. It has the following effects:
This component binds free radical units, prevents excessive oxidation of lipid compounds, maintains the stability of the structure of cell membranes.
It participates in cellular respiration, maintains the desired concentration of high-energy compounds, including ATP, helps glucose to be absorbed better. At the intracellular level, it stimulates the biosynthesis of proteins and polynucleotides. Modulates the activity of ion channels, transport systems of neurotransmitters, acetylcholine, GABA-benzodiazepine and some other receptor complexes. Regulates the work of such enzymes as adenylate cyclase, superoxide dismutase, phosphodiesterase, etc.
Improves nerve conduction, the relationship between various brain structures, the body's resistance to stress, shock, hypoxia, intoxication. Promotes cell proliferation, eliminates damage to the nervous tissue. Increases blood flow, prevents thrombosis, reduces cholesterol level, reduces the manifestations of atherosclerosis, has a beneficial effect on the state and functioning of the myocardium, including with ischemia.
Restores memory, enhances mental activity, eliminates behavioral abnormalities. Slows down the aging process, promotes the rejuvenation of the cellular composition.
What is better than Meciprim or Mexidol?
These drugs are structural analogues, so they are approximately equal in strength and effectiveness. The choice between them should make a doctor. If necessary, one tool can be replaced by another.
Compatibility of mexicrim and mexidol
The drugs in question are not prescribed at the same time. They are well combined with all the therapeutic drugs used to treat somatic lesions, as well as nootropic vitamins and many symptomatic agents.
Dosing and Administration
Antioxidants are prescribed by a doctor. In acute conditions, intramuscular or intravenous (jet or drip) administration is prescribed. For the preparation of an infusion fluid using a physiological solution of sodium chloride, glucose solution or dextrose 5%. Treatment begins with a minimum dosage, gradually increasing to therapeutically effective. Injections are done slowly (5-7 minutes). The recommended single dose is 2-3 mg per 1 kg of body weight. The frequency of injection is 1-3 times a day.
Tablets consumed regardless of the meal. The average daily dosage is 250-500 mg. It is divided into 2-3 doses. The maximum permissible daily dose for all forms is 800 mg. The duration of treatment depends on the characteristics of the pathology and the observed dynamics; on average, it takes 2-3 weeks.
Drugs can increase the proliferation process, so care is needed when prescribing them to patients with diabetic retinopathy. It is recommended to use a short course (up to 10 days).
After completion of injection therapy, oral medication will help fix the results.
Pregnancy and lactation
Studies confirming the safety of the use of hydroxypyridine succinate during gestation and breastfeeding of the infant were not conducted. Therefore, the use of these drugs in pregnant and lactating women is contraindicated.
Clinical data on the possibility of using Mexidol and Meciprima in childhood is not enough. In pediatric practice, they are not used. The age limit is 18 years.
Medicines are indicated for use in old age, including for the prevention of age-related intellectual and mental disorders. The choice of a suitable product, dosage form and dosage depends on the nature of the pathology and the characteristics of its development.
Side Effects of Meciprim and Mexidol
Both drugs are well tolerated. They are characterized by common side effects:
- bouts of nausea;
- drying of the oral mucosa;
- violation of circadian rhythms;
- distal hyperhidrosis;
- anxiety, increased nervous irritability;
- pressure change in one direction or another;
- allergic manifestations (rash, itching, redness of the skin, allergic swelling, bronchospasm);
- problems with coordination of movements.
With a quick injection, you may experience discomfort in the throat and chest, shortness of breath, tachycardia, tremor, feeling of heat, metallic taste in the mouth, olfactory anomalies. With prolonged treatment, peripheral edema, flatulence, bouts of weakness are possible.
Medicines should not be used in case of hypersensitivity to the action of succinate, pyridoxine or auxiliary components. Other contraindications:
- renal dysfunction in the stage of decompensation;
- severe violations of the liver;
- children and adolescents.
Impact on driving
Given the possibility of side symptoms from the central nervous system, caution should be exercised during treatment. when driving or performing other actions that require increased attention and quick psychomotor reactions.
Interaction with other drugs
When used together, enhance therapeutic effects:
- benzodiazepine tranquilizers;
- antianginal nitrate agents;
- antiepileptic and antiparkinsonian drugs (Levodopa, Carbamazepine and their analogues).
Injection solution should not be mixed with any liquids, except for recommended solvents.
Compatibility with alcohol
The active ingredient neutralizes the toxic effects of ethanol. However, during therapy from the use of the latter, including in the composition of drugs, should refrain.
In case of exceeding the recommended doses, sleep and wakefulness may appear, manifested in the form of drowsiness or insomnia. Overdose when using intravenous injections sometimes leads to a short-term increase in blood pressure. If symptoms do not disappear spontaneously within 24 hours, symptomatic agents are prescribed.
Pharmacy sales terms
Medicines must be prescribed.
Medicines need to be protected from children. Store them at temperatures up to + 25 ° C in a dry place, protected from direct sunlight.
Meciprim has a shelf life of 3 years for injections and 5 years for tablets. Regardless of the form of release, Mexidol retains its therapeutic properties for 3 years from the date of manufacture.
Structural analogues of the considered agents are the following representatives of the group of antioxidants and antihypoxants:
- Mexilek et al.
The possibility of replacing the medication should be discussed with your doctor.
Meciprim is cheaper. The average price of tablets in the shell is 147 rubles. for 30 pcs., pricks - 339 rubles. for 10 ampoules The minimum cost of a tableted variety of Mexidol is 235 rubles. for 30 pcs., injection form - 441 rubles. for 10 pcs.
Plakhotnyuk G. V., neurologist, Tula
These are drugs of similar effect. Well help with asthenia and lung neurosis, increase the effectiveness of complex treatment of severe neurological disorders. Allow to reduce the dose of antidepressants, anxiolytics, sleeping pills and neuroleptic drugs.
Ivan, 51 years old, Tver
Meciprim was prescribed when tinnitus appeared. Took 1.5 months, but to no avail.
Inna, 47 years old, Omsk
Mexidol helped my mother-in-law return to active life. She began to get very tired, appeared absentmindedness and apathy. After a course of injections, memory improved, dizziness was gone. She became the same - cheerful and hardworking.