SALOFALK and MESAKOL: what is better and what is the difference (difference of compositions, doctors' opinions)

<div><div> <p>For the treatment of inflammatory diseases of the intestinal mucosa, occurring in a chronic form, doctors often prescribe such drugs as Salofalk or Mesacol. These medicines work well with various microorganisms, reducing the severity of symptoms and slowing the progression of the disease.</p> <figure><img src="/f/5f/a7/5fa7c38afdc40e252e54e6ee772556d1.jpg" alt="For the treatment of inflammatory diseases of the intestinal mucosa, occurring in a chronic form, doctors often prescribe such drugs as Salofalk or Mesacol"><figcaption>For the treatment of inflammatory diseases of the intestinal mucosa, occurring in a chronic form, doctors often prescribe such drugs as Salofalk or Mesacol.</figcaption></figure><h2>Characteristics of drugs</h2> <p>When choosing a drug, it is necessary to take into account its characteristics.</p> <h3>Salofalk</h3> <p>It is an intestinal drug with anti-inflammatory action. It is produced in several dosage forms: in the form of tablets, granules, rectal suppositories, suspensions and foams. The active ingredient is mesalazine. The drug relieves inflammation well, inhibits movement, phagocytosis and neutrophil degranulation, and also slows down the production of immunoglobulins. It is characterized by antibacterial effect and copes well with E. coli and various cocci.</p> <div> <script async src="https://pagead2.googlesyndication.com/pagead/js/adsbygoogle.js"></script> <!-- infoh1 --> <ins class="adsbygoogle" style="display:block" data-ad-client="ca-pub-3781984532523932" data-ad-slot="5787601464" data-ad-format="auto" data-full-width-responsive="true"></ins> <script> (adsbygoogle = window.adsbygoogle || []).push({}); </script> </div> <p>The drug is able to bind with free radicals, leading to their destruction. In addition, it captures such radicals that arise from reactive oxygen compounds. If the drug was administered rectally and orally, then it begins to act within the intestine, practically not penetrating into the systemic circulation.</p> <p>Indications for use:</p> <ul> <li>ulcerative colitis;</li> <li>Crohn's disease.</li> </ul> <blockquote><p>Regularly taking the drug, you can prevent the exacerbation of these diseases. This medication is used with a high probability of developing colorectal cancer and treating hemorrhoids.</p></blockquote> <p>Contraindications include:</p> <ul> <li>blood disorders;</li> <li>severe hepatic or renal failure;</li> <li>hemorrhagic diathesis;</li> <li>stomach ulcer and duodenal ulcer;</li> <li>excessive sensitivity to the components of the drug;</li> <li>age up to 3 years (tablets), up to 6 years (granules);</li> <li>phenylketonuria;</li> <li>deficiency of glucose-6-phosphate dehydrogenase.</li> </ul> <p>Caution is advised to take medication for mild to moderate hepatic and renal failure, bronchial asthma, in the first trimester of pregnancy.</p> <figure><img src="/f/32/98/329868bb068223a123ca58aa03f598a2.jpg" alt="Salofalk is an intestinal drug that has anti-inflammatory effects."><figcaption>Salofalk is an intestinal drug with anti-inflammatory effects.</figcaption></figure><p>Against the background of taking Salofalk, the following side effects may develop:</p> <ul> <li>erythema, fever, pruritus, skin rash, nephrotic syndrome, bronchospasm;</li> <li>myocarditis, acute pancreatitis, interstitial nephritis;</li> <li>flatulence, diarrhea, nausea, loss of appetite;</li> <li>vomiting, abdominal pain;</li> <li>increased blood levels of liver enzymes, hepatitis, jaundice;</li> <li>headache, dizziness;</li> <li>paresthesias, tinnitus, convulsions, tremor;</li> <li>depression, sleep disturbance, peripheral neuropathy;</li> <li>tachycardia, increase or decrease in pressure;</li> <li>chest pain, shortness of breath;</li> <li>agranulocytosis, thrombocytopenia, anemia, leukopenia;</li> <li>myalgia, arthralgia;</li> <li>hypoprothrombinemia;</li> <li>crystalluria, anuria, oliguria, proteinuria, hematuria;</li> <li>reduced production of tear fluid.</li> </ul> <p>According to the instructions for use, the uncontrolled use of large quantities of the drug can lead to an overdose. In this case drowsiness, weakness, vomiting develops.</p> <h3>Mesacol</h3> <p>It is an anti-inflammatory and antimicrobial intestinal agent, which is used to treat ulcerative colitis. It is made in the form of tablets. The main component is mesalazine, which has an antioxidant effect and protects cells from damage. Able to bind free radicals, thereby ceasing to break down the cell membrane.</p> <figure><img src="/f/48/c8/48c85918146197aa33399c0f1ae1c1c8.jpg" alt="Mesacol is an antiinflammatory and antimicrobial intestinal agent used to treat ulcerative colitis."><figcaption>Mesacol is an anti-inflammatory and antimicrobial intestinal agent, which is used to treat ulcerative colitis.</figcaption></figure><p>The drug has antibacterial properties, because it is active against Escherichia coli. Anti-inflammatory effect due to the suppression of the production of inflammatory mediators. Under the action of the drug, the activity of the enzyme lipoxygenase is suppressed and the arachidonic acid cycle is interrupted. This reduces the inflammatory process.</p> <blockquote><p>The active substance is released in the large intestine and lower ileum, where inflammation develops. The drug is practically not absorbed into the systemic circulation, resulting in a local anti-inflammatory effect in the intestine.</p></blockquote> <p>Indications for use:</p> <ul> <li>nonspecific ulcerative colitis;</li> <li>Crohn's disease.</li> </ul> <p>Contraindications include:</p> <ul> <li>blood diseases;</li> <li>excessive sensitivity to the components of the tool;</li> <li>lack of glucose-6-phosphate dehydrogenase;</li> <li>age up to 6 years;</li> <li>severe hepatic and renal failure;</li> <li>hemorrhagic diathesis;</li> <li>stomach ulcer and duodenal ulcer;</li> <li>breast-feeding.</li> </ul> <p>In addition, the drug is not used in the baking of the pancreas due to its toxicity. Caution drug should be taken during pregnancy, with moderate and mild renal and hepatic failure.</p> <p>Taking the medicine can lead to the development of the following side effects:</p> <ul> <li>anemia, a decrease in blood levels of leukocytes and platelets;</li> <li>abdominal pain, loss of appetite, diarrhea, heartburn, nausea, vomiting;</li> <li>pancreatitis, hepatitis, stomatitis, dry mouth;</li> <li>tachycardia, impaired cardiac conduction;</li> <li>pericarditis, shortness of breath, chest pain, increase or decrease in pressure;</li> <li>skin rash, dermatosis;</li> <li>redness, itching, bronchospasm;</li> <li>headache, tremor, polyneuropathy;</li> <li>dizziness, tinnitus;</li> <li>hallucinations, depression, insomnia, convulsions;</li> <li>impaired tear production;</li> <li>baldness;</li> <li>lupus-like syndrome;</li> <li>piggy;</li> <li>weakness.</li> </ul> <p>Overdose may cause drowsiness, weakness, gastralgia, nausea, vomiting.</p> <h2>Comparison of Salofalk and Mesacol</h2> <p>To find out which drug is more effective, it is necessary to compare their characteristics.</p> <h3>Similarity</h3> <p>Both anticancer drugs contain the same active ingredient. They are prescribed to treat Crohn's disease and ulcerative colitis. They have the same contraindications and side effects.</p> <h3>What is the difference?</h3> <p>The difference between the drugs is in the manufacturer and dosage form of release. Mesacol is manufactured in India by Sun Pharmaceutical Industries Ltd. in the form of tablets, and Salofalk is manufactured in Germany by Dr. Falk in the form of tablets, granules, rectal suppositories, suspensions and foams.</p> <h3>What is cheaper?</h3> <p>Salofalk price - 2250 rubles., Mesacola - 740 rubles.</p> <h3>Pharmacy sales terms</h3> <p>Both drugs can be purchased at a pharmacy by prescription only.</p> <h2>Which is better: Salofalk or Mesacol?</h2> <p>The doctor, choosing which drug is better - Salofalk or Mesacol, takes into account the peculiarities of the patient's body, since both drugs are not inferior to each other. However, Salofalk has the following advantages: it is made with high quality, therefore it is highly efficient, and he also has more dosage forms, thanks to which the agent is selected and combined depending on the pathology the patient.</p> <p>For example, granules are used to treat exacerbations, and rectal forms help with isolated lesions of the rectum, which is characteristic of the initial stage of Crohn's disease and ulcerative colitis.</p> <h2>Opinion of patients</h2> <p>Dmitry, 59, Samara: “I have a disease like ulcerative colitis as a result of frequent use of nonsteroidal anti-inflammatory drugs. I went to the doctor who prescribed the drug Salofalk. This drug has helped achieve a stable remission, but it is expensive. There were no side effects during treatment. ”</p> <p>Ekaterina, 44, Chelyabinsk: “I had painful sensations in the intestines as a reaction to antibiotics. The doctor prescribed the medicine Mesacol. I was treated for 2 weeks, as a result of which I began to feel better. The pain passed, but diarrhea was often plagued during therapy. ”</p> <h2>Doctors reviews about Salofalk and Mesacol</h2> <p>Veronika, 55, pediatrician, Moscow: “The drug Salofalk is often used in my practice. It has anti-inflammatory, antibacterial and antioxidant properties. Assign it to children who have autoimmune bowel disease. It is well tolerated and rarely causes the development of negative body reactions. ”</p> <p>Stanislav, 49, gastroenterologist, Murmansk: “I prescribe the drug Mesacol to patients with ulcerative colitis. In most cases, it shows high efficiency, but can lead to the development of side reactions. "</p> </div></div>
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