DE NOL AND PHOSPHOLUGEL: what is better and what is the difference (differences in compositions, reviews of doctors)

Diseases of the stomach and intestinal tract develop on the background of a wrong lifestyle. Getting rid of unpleasant symptoms and returning well-being will be helped by taking drugs such as De-Nol and Phosphalugel.

Diseases of the stomach and intestinal tract develop on the background of a wrong lifestyle, you can be treated with De-Nol and Phosphalugel
Diseases of the stomach and intestinal tract develop on the background of a wrong lifestyle, you can be treated with De-Nol and Phosphalugel.

How to act on the body?

Drugs are representatives of different pharmacological groups. De-Nol has astringent, antiseptic and anti-inflammatory effects. Gently envelops the mucous membrane of the stomach and intestines, protects the organs from aggressive factors of the internal environment (including gastric juice). Increases the resistance of the mucous membrane to the effects of the digestive enzyme, hydrochloric acid, pepsin, bile salts.

Phosphalugel has an adsorbing, coating and acid-neutralizing effect. Creates a protective film on the organs of the gastrointestinal tract, improves the movement of food through the intestines, removes toxins, gases and harmful microorganisms.

Which is better: De-Nol or Phosphalugel?

De-Nol is a gastroprotector, and Phosphalugel is an antacid. They are often appointed together, so it’s not possible to decide which one is better.

In order for the treatment to be as effective as possible, the doctor should be in the choice of drugs.

Indications for use

Conditions for which medication use is indicated:

  • peptic ulcer and duodenal ulcer;
  • gastritis, occurring at a normal or high level of acidity;
  • irritable bowel syndrome caused by the use of poor-quality food, alcoholic beverages, drugs;
  • dyspepsia, not associated with organic pathology of the gastrointestinal tract;
  • other acute and chronic diseases (reflux esophagitis, gastroduodenitis, pancreatitis).

Drug compatibility

Phosphalugel and De-Nol are compatible, so they can be used simultaneously. Drugs complement and reinforce each other, protect the mucous membranes of organs, eliminate the existing symptoms. As a result, the effectiveness of therapy increases, and recovery occurs faster.

The treatment regimen should be the doctor, starting from the collected history and the results of the examination.

Peptic ulcer and duodenal ulcer are the cause of the use of De-nol
Peptic ulcer and duodenal ulcers cause De-nol.

How to take De-Nol and Phosphalugel together?

De-Nol is taken 20-30 minutes before a meal, and Phosphalugel - 2 hours after it. It is important to ensure that at least 2 hours pass between medications.

special instructions

The maximum duration of De Nol treatment is 8 weeks.

During therapy, you must comply with the dosage recommended by the doctor or specified in the instructions for use.

De-Nol may cause darkening of the tongue and feces. This is due to the formation of bismuth sulphide and is considered normal.

If constipation occurs during treatment, you should increase your fluid intake.

Phosphalugel can be taken in case of diabetes mellitus, as well as for preventive purposes (to reduce the absorption of radioactive elements).

Pregnancy and lactation

De-Nol reception is prohibited during periods of gestation and lactation. But Phosphalugel can be used (with the permission of a specialist and in therapeutic doses).


De-Nol can be used from 4 years, and Phosphalugel from 6 months.

Elderly age

Phosphalugel in old age should be used with caution (increased risk of constipation).

Phosphalugel in old age should be used with caution (increased risk of constipation)
Phosphalugel in old age should be used with caution (increased risk of constipation).

Side Effects of De-Nol and Phosphalugel

Medication may be accompanied by disorders in the digestive tract: nausea, vomiting, constipation, frequent stools. These symptoms are short-lived and do not pose a threat to health.

Sometimes patients experience allergic reactions in the form of itching, reddening of the skin, various rashes.

Prolonged use of drugs in high doses can lead to bismuth accumulation in the CNS and the development of encephalopathy.


Restrictions to the simultaneous use of drugs - individual intolerance to the components and pronounced impairment of renal function. Additional contraindications for taking De-Nol are pregnancy and breastfeeding.

In liver cirrhosis, kidney disease and severe heart failure, phosphalugel must be used with caution.

Impact on driving

Drugs do not affect the reaction rate and concentration of attention, so they can be used while driving.

Interaction with other drugs

Within 30 minutes before and after taking De-Nol, it is forbidden to eat food, liquids and other medicines (including antacids). Otherwise, it may reduce the effectiveness of the drug.

During therapy can not use other medicines containing bismuth.

Phosphalugel can affect the efficacy of other medicines. In the presence of concomitant diseases, you should inform the doctor about all medications taken.

Compatibility with alcohol

Phosphalugel is compatible with ethanol and is often used for alcohol intoxication. But during treatment, De-Nol will have to refrain from drinking alcohol. Ethanol can reduce the effectiveness of treatment and cause irreversible destruction of brain cells.


Overdose of drugs leads to inhibition of gastrointestinal motility and impaired renal function.

To therapeutic measures include gastric lavage, taking laxatives and sorbents (including activated carbon). Further therapy should be aimed at eliminating the existing symptoms.

Pharmacy sales terms

You can buy drugs at the pharmacy without a prescription.

Storage conditions

Medicines are kept out of reach of children at a temperature of up to + 25 ° C.

Shelf life

De-Nol retains its properties for 4 years from the date of issue, and Phosphalugel - for 3 years.


De-Nol can be replaced with the following drugs: Novobismol, Vitridinol, Gaviscon, Venter, Gastrofarm, Vikair, Omez D, Vikalin.

Analogues of Phosphalugel are Maalox and Almagel.

Drug price

De-Nol packaging costs 300-800 rubles, and Phosphalugel - 170-370 rubles.


Alexander Sergeevich, gastroenterologist, Moscow: “I prescribe drugs for the elimination of ulcerative processes, the treatment of chronic and acute gastrointestinal diseases. If the pathology proceeds in a mild form, you can do with the use of 1 medication. But in severe cases, Phosphalugel and De-Nol are best taken at the same time. ”

Lyudmila Alekseevna, gastroenterologist, Smolensk: “Preparations have different mechanisms of action, but they work effectively in conjunction. They protect mucous membranes, eliminate inflammatory processes, restore damaged tissue. The advantage is that the acidic environment of the stomach during treatment does not change. "

Anton, 36 years old, Kaliningrad: “I tried to treat heartburn with various folk remedies, but nothing helped. A familiar doctor advised to buy Phosphalugel and De-nol and undergo a course of treatment. The therapy helped, the unpleasant symptom disappeared. ”

Elizaveta, 49 years old: “She worked for 10 years as head of the department. Improper diet, constant stress and lack of sleep - all this led to the development of peptic ulcer. On the advice of a doctor, she was treated with Phosphalugel and De-Nol. Dairy products did not consume, because they can affect the effectiveness of drugs. After a while the pain disappeared. The survey showed that the condition of the organs has improved. ”

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