CORTEXIN AND MEXIDOL: can it be taken simultaneously (compatibility)

Cortexin and Mexidol are drugs used to restore the functions of the central nervous system. They protect tissues from the effects of oxygen starvation and oxidation, restore metabolism and blood circulation. Drugs are effective for ischemic stroke, senile dementia and alcoholic encephalopathy.

Cortexin and Mexidol - drugs used to restore the functions of the central nervous system
Cortexin and Mexidol are drugs used to restore the functions of the central nervous system.

How to act on the body?

Cortexin contains peptides extracted from pigs' cortex. The drug penetrates well through the blood-brain barrier, enhancing the production of proteins necessary for the normal functioning of nerve cells. Cortexin protects the vascular walls from oxidation, maintains a balance between the processes of inhibition and excitation in the cerebral cortex. The active substance restores memory, reduces the frequency of epileptic seizures.

Mexidol improves energy metabolism in nerve cells, increases the resistance of tissues under hypoxic conditions. The active element protects the membranes of neurons from oxidation that occurs in stressful situations. Other useful properties of the drug include improving the rheological properties of blood. Stabilization of platelet membranes prevents their gluing. Unlike antiplatelet agents, Mexidol does not cause hemorrhagic complications.

What is the difference?

Cortexin is a natural remedy, produced on the basis of protein components of the cerebral cortex of pigs. Available in the form of a lyophilisate, which by mixing with procaine turn into a solution for injection. Mexidol is an artificial drug used in the treatment of complications of hypoxia. The drug is in the form of tablets or solution.

Which is better - Cortexin or Mexidol?

The drugs have slightly different effects on the body, so it is difficult to say which one is better.

Indications for use

The indications for the use of Mexidol and Cortexin are such pathological conditions:

  • ischemic stroke;
  • post-traumatic encephalopathy;
  • alcoholic brain damage;
  • epilepsy;
  • Alzheimer's disease;
  • complication after brain surgery;
  • pancreatitis;
  • vascular dystonia.
Mexidol is used if an ischemic stroke has occurred.
Mexidol is used if an ischemic stroke has occurred.

How to take Cortexin and Mexidol together?

Despite the fact that drugs have similar actions, it is impossible to mix solutions in one syringe. It is recommended to do injections with interruptions for at least 2 hours or to combine injection and tablet form preparations.

Special instructions for the use of Cortexin and Mexidol

In some cases, a dose adjustment or refusal to administer Mexidol or Cortexin is required.

Pregnancy and lactation

The safety of active substances for the fetus is not proven, so the drugs should not be used during pregnancy. Contraindication is breastfeeding.


According to the instructions for use, Mexidol is contraindicated in patients younger than 16 years. Cortexin is not recommended for children whose weight does not exceed 10 kg.

Elderly age

In the absence of contraindications, drugs are administered in standard doses.

Side effects

With the introduction of drugs may experience the following side effects:

  • lowering blood pressure, headache, dizziness;
  • nausea and vomiting, dry mouth, loose stools;
  • allergic reactions in the form of skin rashes, urticaria, angioedema.
In the elderly, in the absence of contraindications, Cortexin is administered in standard doses.
In old age, in the absence of contraindications, Cortexin is administered in standard doses.


Medicines do not apply for allergic reactions to the components of the solution or tablets, severe violation of the functions of the liver and kidneys.

Impact on driving

Drugs can cause neurological disorders, accompanied by a decrease in concentration and speed of psychomotor reactions. During the period of treatment is to refrain from driving.

Interaction with other drugs

Mexidol and Cortexin increase the action of antihypertensive, anticonvulsant, nootropic and anti-Parkinsonian drugs.

Compatibility with alcohol

Do not use drugs in combination with ethyl alcohol.


Repeated excess of the dose prescribed by the doctor contributes to vomiting, severe headaches and dizziness. Consciousness and coordination of movements may be impaired.

Pharmacy sales terms

Mexidol and Cortexin are only available on prescription.

Storage conditions

Ampoules with solution and tablets are stored in a cool place, protected from sunlight.

Shelf life

The preparations are suitable for use within 36 months from the date of production.

What can replace

Mexidol and Cortexin can be replaced with the following analogues:

  1. Actovegin.
  2. Mexprim.
  3. Ethoxidol.
  4. Cerebrolysin.

Drug price

The average price of Mexidol is 1200 rubles. for 10 ampoules, the packaging of Cortexin will cost 800 rubles.


Alexander, 45, neurologist, Saratov: “Mexidol and Cortexin are widely used in neurology. They help to cope with the effects of stroke, cerebrovascular accident and encephalopathy of any origin. Increasing the resistance of nerve cells to oxygen deficiency helps to avoid the development of dangerous complications. Drugs have a minimum number of contraindications and side effects. "

Pavel, 38, Nevinnomyysk: “I had a head injury at work, after which I had to recover for a long time. The consequence was panic attacks. The attack was accompanied by rapid heartbeat, increased pressure, a sense of fear. He turned to a neurologist who prescribed a combination of Mexidol and Cortexin. Injections were made during the month. This helped reduce the frequency of panic attacks, get rid of headaches, and normalize sleep. ”

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