NATALSID and RELIFE: what is better and what is the difference (difference of compositions, doctors' opinions)

For the treatment of rectal cracks and hemorrhoids, doctors often prescribe rectal suppositories. The most effective drugs are Natalsid and Relief. They help relieve inflammation, stop bleeding, eliminate swelling, promote healing of rectal mucosa.

Natalcid and Relief help relieve inflammation, stop bleeding, promote healing of rectal mucosa
Natalcid and Relief help relieve inflammation, stop bleeding, promote healing of rectal mucosa.

Characteristics of drugs

Choosing a drug, you need to know its characteristics.


This is a local drug that has hemostatic, wound healing and anti-inflammatory effects. It is used to treat anal fissures, hemorrhoids and proctosigmoiditis. Available in the form of suppositories. The main component is sodium alginate. Rectal candles are prescribed for the treatment of diseases of the anus.

The composition of the drug includes hyaluronic acid, which regulates the process of cell division. Under its influence, normal cells of the mucous membrane of the large intestine, the walls of the hemorrhoidal veins and the anal sphincter begin to multiply rapidly. This is due to the healing effect of the drug.

Another structural component is alginic acid, which, when released into the rectum, swells severely, forming a gel-like substance. This substance envelops the walls of hemorrhoidal veins and intestines, thereby providing an analgesic effect. Alginic acid is able to react chemically with sodium, which results in the formation of salt, which reduces excessive intestinal activity, which leads to the normalization of stool.

Natalside is characterized by a pronounced anti-inflammatory effect, which allows reducing inflammation several times in a week after taking the drug, and after 14 days it is completely eliminated. The drug stimulates the production of immunoglobulin type A, which is an important link in the local mucosal immunity colon and anal sphincter, thereby increasing its resistance to the negative effects of pathogenic microorganisms.

Natalcid is used for colitis, proctosigmoiditis, bleeding hemorrhoids, pain during defecation
Natalcid is used for colitis, proctosigmoiditis, bleeding hemorrhoids, pain during defecation.

Indications for use:

  • chronic anal fissures;
  • colitis;
  • proctosigmoiditis;
  • bleeding hemorrhoids;
  • pain during stool;
  • intestinal pathologies occurring in acute form with a lesion of the colon wall (dysentery, salmonellosis);
  • bleeding or inflammation that occurred after surgery on the colon.


It is a drug that has local anesthetic and anti-inflammatory effects, used in proctology. Available in the form of rectal suppositories and cream. The main components are lidocaine hydrochloride, fluocortolone pivalate.

The analgesic effect is provided by lidocaine, which prevents the formation and conduction of nerve impulses along the nerve fibers by means of the depolarization of sodium channels. Thanks to fluocortolone, neutrophil accumulation is prevented, macrophage movement is inhibited, and the level of lymphokines decreases. This reduces the processes of infiltration, granulation and exudation.

In addition, Relief has the following actions:

  • inhibits inflammatory and allergic skin reactions;
  • reduces itching, burning and pain;
  • reduces interstitial edema, tissue infiltration and capillary dilatation.

The drug is prescribed for the treatment of internal and external hemorrhoids. It helps well with anal itching and cracks in the anus, as well as erosion and microtrauma of the anus.

Taking the drug for more than a month can lead to the development of local skin changes: telangiectasia, atrophy, stretch marks.

If you accidentally take the medication inside, it can develop severe side effects: depression of cardiac activity, cardiac arrest, convulsions, impaired and stopped breathing.

Relief prescribed for the treatment of internal and external hemorrhoids
Relief prescribed for the treatment of internal and external hemorrhoids.

Comparison of Natalside and Relief

To compare drugs, you need to study their characteristics.


Both drugs are used to treat anal fissures and hemorrhoids. They have a vasoconstrictor, hemostatic and anti-inflammatory action. These medicines are not recommended to be used without consulting a doctor, because they can cause side effects and complications.

What's the Difference?

Relief eliminates the following symptoms: pain in the anus and anal itching, and Natalcid can only relieve pain. The drugs have different active ingredients, and they are available in various dosage forms. Natalcide is a completely natural remedy, and its active ingredient is derived from brown algae. Relief made from extracts of plant and animal origin. In addition, this drug has more contraindications.

What is cheaper?

Price Natalsida - 390 rubles. Relief - 470 rubles.

Pharmacy sales terms

Both drugs are dispensed from pharmacies without a prescription.

Which is better - Natalsid or Relief?

Choosing which drug to prescribe - Natalsid or Relief, the doctor takes into account the symptoms of the disease and the characteristics of the patient. Natalcid is effective in bleeding hemorrhoids, because it promotes more rapid healing of the tissues and stop bleeding. Most often, it is prescribed at the initial stage of the disease, when blood appears after emptying.

Relief helps with anal itching, which appears due to swelling of the mucous membrane. The drug is effective in chronic hemorrhoids.

If the patient has hemorrhoids of blood flow, pain and inflammation, then Natalcide is recommended, which eliminates such negative reactions.

During pregnancy

During pregnancy, Natalsid is often prescribed, since it is safer than Relief, which is prohibited in the first trimester.

Can I take at the same time?

The combined use of 2 rectal preparations is not recommended.

How to use?

Candles must be inserted into the anus after a cleansing enema or emptying. Wash hands and anus area before the procedure. You need to lie on your side and enter the suppository into the rectum with your index finger as deep as possible. Ointment is used internally and externally, introducing with the help of nozzles-applicator.

The doctor prescribes Relief 1 candle 1-4 times a day, Natalcid 1-2 times a day. The duration of treatment is 10 days.

Contraindications and side effects

Contraindications Natalsid include:

  • excessive sensitivity to the components of the tool;
  • age up to 14 years.

The only side effect is an allergic reaction to the drug (pruritus, rash, urticaria).

Relief contraindications include:

  • syphilitic and tuberculous processes at the site of application;
  • first trimester of pregnancy;
  • viral diseases in the field of application of the medication (shingles, chicken pox);
  • excessive sensitivity to the components of the tool;
  • age up to 18 years.

Allergic reactions are extremely rare.

Reviews of Natalside and Relief

Dmitry, 56, proctologist, Moscow: “I consider the preparation Natalsid to be the best in coloproctology. It shows high efficacy with minimal contraindications. Extremely rarely causes adverse body reactions. The cost of the drug is quite high, but it is compensated by its positive qualities. ”

Gennady, 51, surgeon, Tver: “Relief is often prescribed to patients with perianal and anal fissures. It relieves inflammation and itching well. Rarely causes side effects. ”

Svetlana, 39 years old, Samara: “My hemorrhoids are regularly exacerbated after I lift something heavy. In this case, come to the aid of candles Natalsid. They quickly eliminate inflammation and pain. ”

Catherine, 23 years old, Syzran: “After the birth, hemorrhoids appeared. The doctor prescribed Relief candles, which I used for the night, and Relief treated the sore spot 5 times a day with ointment. Thanks to this treatment, I managed to get rid of the problem in 7 days. ”

  • Share