Antioxidants and antihypoxants have a wide range of applications, are used in various branches of medicine. Examples of such drugs are drugs Mexidol and Ethoxidol.
How to act on the body?
Drugs are inhibitors of free radical processes. They have a membrane-protective, anticonvulsant, anti-toxic, stress-protective, anxiolytic and nootropic action.
Pharmacodynamics of drugs is similar. Drugs increase the body's resistance to the effects of damaging factors, reduce platelet adhesion, improve blood microcirculation and its rheological properties. They have anti-ischemic properties, reduce LDL and total cholesterol.
During therapy, normal blood circulation in the brain. The result is improved memory and learning ability, the elimination of somatovegetative disorders and sleep disorders, increased stress tolerance. Drugs help with alcohol intoxication and withdrawal symptoms: relieve symptoms of poisoning, restore autonomic functions, eliminate cognitive and behavioral disorders.
Pharmacokinetics of drugs is similar. After oral administration, they are completely absorbed, quickly distributed to tissues and organs. Ethoxidol is retained in the body longer, the maximum concentration with the introduction of the solution is achieved faster.
What's better? Mexidol and Etoxidol
To say which drug is better, it is possible only after collecting the history and diagnosis. Mexidol has a wider range of applications, can be used for ischemic disease, glaucoma, traumatic brain injury, stress, peritonitis and pancreatitis.
Ethoxidol is absorbed faster and begins to act earlier, it is characterized by ease of use (tablets can not only be swallowed, but also chewed). The disadvantages of the drug include a low content of the active substance (you have to take more pills) and a large number of auxiliary components (more often allergic reactions).
If the doctor offers the patient to choose the drug, you should start from the existing contraindications and the cost of the drug.
Indications for use
The therapeutic properties of medicines allow their use in the following cases:
- disorders of cerebral circulation (acute and chronic);
- vascular dystonia;
- cognitive impairment;
- anxiety disorders;
- abstinence syndrome in alcoholics;
- encephalopathic disorder (dyscirculatory, post-traumatic, dismetabolic, mixed);
- acute poisoning with antipsychotic drugs.
Additional indications for taking Mexidol are:
- ischemic heart disease associated with circulatory disorders;
- head injuries and their consequences;
- exposure to extreme factors and prevention of the development of somatic diseases;
- peritonitis, pancreatitis.
Dosing and Administration
Detailed information on the use of drugs is in the instructions for use. Mexidol tablets are taken three times a day, 125-250 mg (no more than 6 tablets per day). The duration of treatment for coronary artery disease is 1.5-2 months, with withdrawal syndrome - 5-7 days, in other cases - 2-6 weeks. The solution is administered intravenously (drip, stream) or intramuscularly. When performing infusions, Mexidol is diluted in 0.9% sodium chloride solution. The maximum daily dose is 1200 mg.
Chewable tablets Ethoxidol should be taken with water. Treatment of stroke and coronary artery disease begin with 3 tablets per day, then increase the dose to achieve the desired effect. For 1 time you can take up to 200 mg of the drug, for 1 day - 800 mg. The minimum duration of a course is 2 months. The drug improves memory and eliminates cognitive disorders, if you take it 3-4 times a day, 100 mg.
Ethoxidol solution in ampoules is intended for intramuscular and intravenous administration. Injections are made from 1 to 3 times a day, 50-100 mg of the drug are administered at a time. Subsequently, the dose may be increased up to the maximum (800 mg).
When using Mexidol, some patients (especially asthmatics with individual sulfite intolerance) may develop severe hypersensitivity reactions.
Pregnancy and lactation
Ethoxidol is forbidden to take during lactation and gestation. Mexidol is not recommended for use during these periods.
Giving drugs to children and adolescents is undesirable.
When treating elderly patients with anxious and mild cognitive impairments, Etoxidol is injected intramuscularly in a dose of 100-300 mg per day. Course duration varies from 14 to 30 days.
Side effects of Mexidol and Etoxidol
During treatment, adverse reactions may occur:
- dry mouth, the presence of metallic taste;
- chest discomfort, lack of air (at a high rate of solution injection);
- drowsiness, decreased concentration and reaction rate;
- allergic manifestations.
Contraindications to the use of Mexidol and Etoxidol
Medicines are not prescribed in the following cases:
- severe liver and kidney function;
- individual intolerance to the components;
Impact on driving
Drugs can reduce the speed of reaction and concentration of attention, so drivers of vehicles and production workers should be careful during treatment.
Interaction with other drugs
Medicines are able to interact with other drugs:
- enhance the effect of anticonvulsants;
- increase the effectiveness of anti-Parkinsonian and nitrate drugs;
- enhance the positive effects of neuroleptics, hypnotics, antidepressants, tranquilizers;
- reduce the toxic effect of drugs for chemotherapy.
Compatibility with alcohol
Drinking alcohol during treatment is possible, but in reasonable quantities.
With increased use of drugs, symptoms of overdose develop: drowsiness, insomnia, high blood pressure. To eliminate them, symptomatic therapy is carried out.
Pharmacy sales terms
A prescription is needed to buy drugs.
The place of storage of medicines should be dark, cool (up to + 25 ° C), inaccessible to children.
Tablets and Mexidol solution can be used for 3 years. Ethoxidol tablets retain useful properties for 3 years, and the solution - 2 years.
Analogs of drugs in tablets: Hypoxen, Cerebronorm, Memoria, Glycine, Cytoflavin, Polinevrin.
Analogues in ampoules: Hypoxen, Cortexin, Vitagamma, Kombilipen, Trigamma, Emoksibel, Tsitoflavin.
Mexidol costs 250-2000 rubles, and its equivalent - 600-1500 rubles.
Alexey Gennadievich, neurologist, St. Petersburg: “I prescribe drugs for disorders of brain activity. They are highly efficient, do not cause adverse reactions, they are cheaper than many other analogues. ”
Irina, 38, Krasnodar: “She gave Mexidol to her mother, who suffered a head injury during an accident. Thanks to the drug, the recovery was quick and without complications. ”
Michael, 54 years old, Izhevsk: “I suffer from vegetative-vascular dystonia and take Etoxidol on the advice of a doctor. The symptoms are gone, I feel much better. The doctor allowed the course to be repeated to fix the result. ”