Medications such as Mildronate and Mexidol should only be used as directed by the doctor. However, it is necessary for everyone who needs them to know the specifics of single-type preparations, since the effectiveness of the use of a particular agent can be assessed individually and subjectively.
Indications for use
Mildronate is used for:
- alcoholism during the period of abstinence;
- rehabilitation after a stroke;
- cardiovascular diseases;
- chronic fatigue;
- angina pectoris;
- retinal hemorrhage;
- prolonged overvoltage;
- quick fatigue and low performance.
Thus, this drug is used to increase the stamina of a healthy person and improve the condition of people with symptoms of vascular disorders in the heart and brain.
Mexidol is prescribed to patients suffering from:
- memory impairment;
- the effects of traumatic brain injury;
- heart myocardiodystrophy;
- vegetative dystonia;
- anxiety disorders with anxiety disorders;
- open-angle glaucoma;
- catarrhal diseases in severe form;
- intoxication arising during withdrawal and poisoning with psychotropic drugs;
- acute necrotizing pancreatitis;
What is the difference between drugs
Mildronate and Mexidol differ in chemical composition and some features of the effects on the body. Despite the fact that they are used for intoxication, as well as to improve blood circulation in diseases of the heart and brain, these drugs can not be considered analogues. The fact is that meldonium is a means of stimulating the activity of the heart and the central nervous system through the normalization of the oxygen balance and the transport of ATP. Mexidol also has a beneficial effect on the heart and central nervous system, but due to the activation of metabolic processes and effects on cell membranes.
Characteristics of active substances
Mildronate is available in the form of capsules containing a white powder, as well as in the form of ampoules for injection. Meldonium dihydrate is an analogue of gamma-butyrobetaine produced by the human body. Reception of synthetic meldonium contributes to:
- improve ATF transport;
- increased glycolysis;
- increase performance;
- restoration of the oxygen balance in the cells;
- improving immunity;
- elimination of symptoms of physical and mental fatigue;
- slowing the formation of tissue necrosis during ischemia;
- improvement of blood circulation during ischemic disorders in the brain;
- prevention of fundus dystrophy;
- increase the tone of the central nervous system;
- elimination of withdrawal symptoms.
Meldonium acts quickly due to the high efficiency of absorption. Metabolism of the drug occurs in the liver. Displays medication through the kidneys.
Mexidol is available as a solution for injection, both intramuscular and intravenous, as well as in the form of tablets. The active ingredient is ethylmethylhydroxypyridine succinate, which:
- increases the body's resistance to the effects of damaging factors;
- improves metabolism in the central nervous system and heart;
- reduces red blood cell aggregation;
- stabilizes platelet and red blood cell membranes;
- eliminates the symptoms of intoxication with alcohol and neuroleptics;
- reduces the level of endogenous intoxication in acute forms of diseases (influenza, tonsillitis, pancreatitis, bronchitis, lung diseases);
- inhibits lipid oxidation;
- increases the concentration of dopamine in the central nervous system;
- increases the intensity of coronary blood flow;
- lowers cholesterol;
- activates the physiological processes in the retina and optic nerve.
The pharmacokinetics of Mexidol are as follows:
- maximum concentration occurs in 35-45 minutes;
- the retention time of the active substance is about 1 hour;
- present in blood plasma within 4 hours after administration;
- excreted through the kidneys.
Which is better - Mexidol or Mildronat
In order to understand what is better - Mexidol or Mildronate, you need to know the condition of the patient and the causes of his illness. The first drug is used only by people suffering from heart disease and circulatory disorders in the central nervous system. The second drug can also be used as a tonic for overloading.
Compatibility of Mexidol and Mildronata
The possibility of simultaneous use of these drugs has been proven in practice. However, it is necessary to take into account the fact that in this case their action is enhanced.
Dosing and Administration
Mildronat's treatment courses depend on the diagnosis and condition of the patient. For the treatment of diseases such as heart attack, angina, heart failure, doses of 500-1000 mg per day are prescribed.
Dishormonal cardiomyopathy requires a dosage of not more than 500 mg per day. A similar dose requires recovery after a stroke.
The use of the drug as a means of improving the overall physical and mental state, allows an increase in daily dosage to 1000 mg. However, the reception should be carried out twice a day, 500 mg.
Treatment of withdrawal symptoms requires an increase in daily doses up to 2000 mg. However, the reception is carried out 4 times a day, 500 mg.
Mildronate in ampoules is used for parabulbar injections. The dosage is determined by the doctor, based on the patient's condition.
Mexidol is used intramuscularly and intravenously. In the latter case, the introduction is carried out as a jet, and drip. During the day, you can enter only 1200 mg of solution.
Since Mildronate stimulates the central nervous system, it is recommended to use it only in the morning. Otherwise, insomnia may occur.
Mexidol can lead to drowsiness, so stabbing it is desirable at a time when a person has the opportunity to rest. In addition, patients suffering from bronchial asthma may experience hypersensitivity or a paradoxical reaction.
Pregnancy and lactation
Since both drugs cannot be given to children, they should not be given to pregnant and lactating women.
The effect of Meldonium and Mexidol on people under the age of 18 years has not been adequately studied, so the use of drugs in children is unacceptable.
Elderly restrictions for these drugs are not provided. However, the invigorating effect of Mexidol should be taken into account. In people with age-related diseases, it can lead to sleep disorders and neurosis.
Side effects of Mexidol and Mildronata
The main undesirable side effect when using meldonium is an increase in nervous excitability due to the exhilarating effect that is too high for a given patient.
In addition, it is possible:
- differential blood pressure;
When using Mexidol may appear:
- dry mouth;
In addition, the injection of this drug is sometimes accompanied by the flashing of the flies. After this, weakness and drowsiness may occur.
Mildronate is prohibited to use in the following cases:
- during pregnancy and lactation;
- under the age of 18;
- with brain tumors;
- with high intracranial pressure.
Care is required when treating patients suffering from renal and hepatic insufficiency with meldonium.
Mexidol is contraindicated in people suffering from liver and kidney failure and individual intolerance to the drug.
Impact on driving
There is no evidence of the adverse influence of Meldonium on the transport management process. However, in the event of side effects, an increase in blood pressure is possible, which may affect the behavior of the person behind the wheel.
When using Mexidol should take into account the appearance of drowsiness.
Interaction with other drugs
Allowed to mix Mildronata with such drugs:
- antiplatelet agents.
When used together with meldonium coronarodilatiruyuschimi and sedatives, the action of the latter is enhanced. A similar situation is observed when interacting with cardiac glycosides.
Since in some cases, taking Mildronate can lead to a decrease in pressure, it should not be combined with nitroglycerin, nifedipine and alpha-blockers.
Mexidol enhances the action of anticonvulsant and anti-Parkinsonian drugs and benzodiazepine derivatives.
Compatibility with alcohol
Mildronate and alcohol affect the circulatory system and the central nervous system. If alcohol is taken regularly throughout the course of treatment, then the effectiveness of Mildronate is greatly reduced.
It is undesirable to take alcohol in the treatment of Mexidol. However, in this case, you should take into account the fact that this drug reduces the toxic effect of ethyl alcohol.
After taking higher doses of Meldonium, a sharp decrease in blood pressure is possible. As a result, dizziness, tachycardia, headache, weakness appear.
After taking higher doses of Mexidol, drowsiness is so severe that a person cannot control himself.
Pharmacy sales terms
Both drugs are available only by prescription. Restrictions on the availability of drugs are associated with high risks of side effects if used improperly.
Drugs should be stored in a dry and cool place (from +10 to + 25 ° C).
Capsules and ampoules Mildronata stored no more than 4 years. Mexidol's shelf life is less than 3 years.
Mildronat has the following analogues:
Mexidol is similar to drugs:
The average price of Mildronate capsules is 280 rubles, ampoules - 360 rubles.
The cost of Mexidol varies depending on the form of release and the number of units. Packing 30 tablets will cost 350 rubles, 50 - 500 rubles. The solution for injection will cost 560 (10 ampoules), 1300 (20 ampoules) and 2300 (50 ampoules) rubles.
Igor, 32 years old Permian
I want to praise meldonium. In vain he was counted as doping. It does not interfere with biochemical processes, but helps people overcome overloads. It is good that mountaineering is not an Olympic sport. So we conquer peaks with this tool.
Irina, 28 years old, Moscow
My mother treated insomnia with Mexidol. And what is interesting - it helped. Now do without sleeping pills.